C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/270.5
C07D 451/10 (2006.01)
Patent
CA 1215714
TROPYL AND PSEUDOTROPYL ALKYL-BENZOATES AND THEIR USE IN MIGRAINE TREATMENT ABSTRACT OF THE DISCLOSURE Migraine is treated with a pseudotropyl or tropyl benzoate derivative of the following general Formula I:- Image wherein:- Ar represents Image n represents O or an integer from 1 to 3 R1 represents C1-C4 alkyl; R2 represents C1-C4 alkyl, C1-C4 alkoxy or halogen provided that R2 is the same as R1 when n is 2 or 3; and R3 and R4 independently represent hydrogen, C1-C4 alkyl, C1-C4 alkoxy, or halogen provided that for tropyl derivatives R3 is alkyl and R4 is hydrogen; or a pharmaceutically acceptable salt thereof. With the exception of tropyl-2-methylbenzoate, the derivatives of Formula I are novel compounds.
417497
Fozard John R.
Gittos Maurice W.
Merrell Toraude Et Compagnie
Osler Hoskin & Harcourt Llp
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