Trpv1 agonists, formulations containing them and uses thereof

Details Trpv1 agonists, formulations containing them and uses thereof Trpv1 agonists, formulations containing them and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 235/28 (2006.01) A61K 31/16 (2006.01) A61P 13/00 (2006.01) A61P 25/00 (2006.01) C07C 235/26 (2006.01) C07D 303/46 (2006.01)

Patent

CA 2575341

The compounds of the general formula (I) in which X is represents two hydrogen atoms, a .pi.-bond, oxygen or methylene; R2 is a C6-C12 aryl, or arylalkyl residue; R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of pathologies mediated by vanilloid receptors type I.

L'invention concerne des composés représentés par la formule générale (I), dans laquelle X représente deux atomes d'hydrogène, une liaison p, oxygène ou méthylène; R2 représente aryle C6-C12 ou un résidu arylalkyle ; R3 représente hydrogène, 2-hydroxyéthyle ou 2-aminoéthyle. Ces composés sont utiles pour le traitement d'états pathologiques médiées par des récepteurs vanilloïdes du type I.

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