Truncated aggrecanase molecules

Details Truncated aggrecanase molecules Truncated aggrecanase molecules

C - Chemistry, Metallurgy

12

Q

C12Q 1/37 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2475329

Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.

La présente invention concerne des protéines d'aggrécanase tronquées et des séquences de nucléotides codant pour celles-ci, ainsi que des procédés pour les produire. L'invention a également pour objet des aggrécanases qui comportent des mutations d'acides aminés et conduisent à une meilleure stabilité et des niveaux d'expression supérieurs en comparaison avec les aggrécanases de type sauvage ou natives. Les aggrécanases de l'invention sont particulièrement utiles pour mettre au point des compositions destinées au traitement de maladies telles que l'ostéoporose. L'invention concerne également des procédés pour mettre au point des inhibiteurs des enzymes d'aggrécanases et des anticorps anti-enzymes d'aggrécanases pour traiter les états pathologiques se caractérisant par la dégradation de l'aggrécane.

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