C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2520097
The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered 0-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders.
La présente invention concerne une glycoprotéine BAFF-R qui n'est pas naturelle, qui présente dans le domaine extracellulaire une délétion produisant un motif de O-glycosylation modifié. L'invention se rapporte également à des procédés et à des compositions pharmaceutiques permettant de traiter des troubles médiés par les lymphocytes B et T.
Ambrose Christine
Hsu Yen-Ming
Sun Yaping
Thompson Jeffrey
Wen Dingyi
Biogen Idec Ma Inc.
Gowling Lafleur Henderson Llp
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