C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07K 14/71 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2381241
The present invention relates to truncated EGF receptor molecules that exhibit increased binding affinities for EGFR ligands such as EGF and TNFI. The present invention also relates to methods of screening for EGF receptor ligands and methods of treatment which involve the use of these molecules.
La présente invention concerne des molécules réceptrices de EGF tronquées qui présentent une affinité de liaison élevée pour les ligands de EGFR, tels que EGF et TNFI. Par ailleurs, cette invention concerne des méthodes de criblage des ligands des récepteurs de EGF ainsi que des méthodes de traitement faisant intervenir ces molécules
Adams Timothy Edward
Burgess Antony Wilkes
Domagala Teresa Anne
Elleman Thomas Charles
Garrett Thomas Peter John
Biomolecular Research Institute Limited
Commonwealth Scientific And Industrial Research Organisation
Ludwig Institute For Cancer Research
Sim & Mcburney
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