Truncated forms of human dbf4, complexes with their...

Details Truncated forms of human dbf4, complexes with their... Truncated forms of human dbf4, complexes with their...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2524528

The present invention generally relates to the desing, expression and purification of truncated forms of the human dbf4 protein, optionally in complexe with dbf4 interacting partners, such as human cdc7, and its use in the discovery, indentification and characterization of inhibitors of the components of the complex, either when associated or when present as uncomplexed proteins in situ or in vitro. More specifically, the present invention relates to the utilization of specific truncated forms of human dbf4 for the production of an active, non-aggregated, monodispersed hetorodimer of human dbf4 complexed to human cdc7, or other protein interactors.

La présente invention concerne globalement la conception, l'expression et la purification de formes tronquées de la protéine dbf4 humaine, éventuellement dans un complexe avec des partenaires d'interaction de dbf4, telles que la cdc7 humaine, et son utilisation dans la découverte, l'identification et la caractérisation d'inhibiteurs des composants du complexe, soit lorsqu'ils sont associés, soit lorsqu'ils sont présents sous forme de protéines isolées in situ ou in vivo. La présente invention concerne plus précisément l'utilisation de formes tronquées spécifiques de la dbf4 humaine pour la production d'un hétérodimère monodispersé, non regroupé, actif, de la dbf4 humaine, combiné à une cdc7 humain, ou à tout autre élément d'interaction avec la protéine.

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