Truncated forms of the hepatocyte growth factor (hgf) receptor

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/18 (2006.01) A61K 38/27 (2006.01) C07K 14/61 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2102595

A protein, which is useful as an antagonist of hepatocyte growth factor; is composed of two disulphide-linked chains of 50 kDa and 75 or 85 kDa respectively; the 50 kDa chain being the .alpha.-chain of the tyrosine kinase encoded by the MET protoonco- gene and the 75 or 85 kDa chain being a C-terminal truncated form of the .beta.-chain of the said tyrosine kinase.

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