C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61P 29/00 (2006.01) C07K 14/715 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/24 (2006.01) C07K 14/54 (2006.01)
Patent
CA 2638864
The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-17A alone, or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. IL-17RA is a receptor for IL-17A and does also bind IL-17F. The present invention includes a truncated soluble IL- 17RA, as well as methods for antagonizing IL-17A or both IL-17A and IL-17F using such a truncated soluble receptor.
La présente invention concerne le blocage, l'inhibition, la réduction, la production d'effets antagonistes ou la neutralisation de l'activité de l'IL-17A seule ou des deux molécules polypeptidiques IL-17A et IL-17F. L'IL-17A et l'IL-17F sont des cytokines qui participent aux processus inflammatoires et à la maladie humaine correspondante. L'IL-17RA est un récepteur de l'IL-17A et il se lie également à l'IL-17F. La présente invention concerne un IL-17RA soluble tronqué, ainsi que des procédés permettant d'obtenir des effets antagonistes contre l'IL-17A ou contre à la fois l'IL-17A et l'IL-17F en utilisant un tel récepteur soluble tronqué.
Gao Zeren
Levin Steven D.
Rixon Mark W.
Stevens Brenda L.
Smart & Biggar
Zymogenetics Inc.
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