C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/25 (2006.01) A61K 31/70 (2006.01) A61K 35/32 (2006.01) A61K 38/20 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/715 (2006.01) C12N 5/10 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2098848
2098848 9211359 PCTABS00014 The subject invention concerns a method of using in vivo a gene encoding an extracellular interleukin-1 binding domain of an interleukin-1 receptor that is capable of binding to and neutralizing interleukin-1 which includes employing recombinant techniques to produce a cell line under the control of a suitable eukaryotic promoter having the gene coding for the extracellular interleukin-1 binding domain of the interleukin-1 receptor; and initiating transfection of DNA of the gene by introducing viral particles obtained from the cell line directly into synovial cells lining a joint space of a mammalian host. Alternatively, synovial cells from the patient's joint may be transduced with the retroviral vector carrying the therapeutic gene and a selectable marker for selection of only transduced cells, and the now therapeutic autologous cells may be introduced back into the joint by transplantation. Additionally, a method of preparing a gene encoding an extracellular interleukin-1 receptor binding domain of an interleukin-1 that is capable of binding to and neutralizing interleukin-1 is disclosed. A compound for parenteral administration to a patient in prophylactically or therapeutically effective amounts containing the gene of the invention and a suitable pharmaceutical carrier is also provided.
Bandara Geethani
Evans Christopher H.
Glorioso Joseph C.
Robbins Paul D.
Marks & Clerk
University Of Pittsburgh Of The Commonwealth System Of Higher Ed
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