C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01)
Patent
CA 2685672
The invention relates to mTORbeta, a splice form of mTOR, nucleic acids encoding mTOR beta, and antibodies against mTOR beta. The invention also relates to methods of producing mTOR beta and methods of screening for an agent that modulates mTOR beta expression and/or activity. The invention further relates to a method of treating a disease associated with aberrant expression of mTOR beta by administration of an agent that alters mTOR activity and/or expression.
L'invention porte: sur la mTORbêta, forme épissée de la mTOR, sur des acides nucléiques codant pour la mTORbêta et sur des anticorps anti mTORbêta. L'invention porte également sur des méthodes de production de la mTORbêta, sur des méthodes de criblage d'un agent modulant l'expression et/ou l'activité de la mTORbêta. L'invention porte en outre sur une méthode de traitement d'une maladie associée à l'expression anormale de la mTORbêta, par administration d'un agent qui en modifie l'activité et/ou l'expression.
Gout Ivan
Nemazanyy Ivan
Panasyuk Ganna
Waterfield Michael
Zhyvoloup Alexander
Ludwig Institute For Cancer Research
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ucl Business Plc
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