C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/30 (2006.01) A61K 39/005 (2006.01) A61K 39/395 (2006.01) C07K 14/44 (2006.01) C07K 16/20 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/70 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2313609
The nucleotide sequence of Tc40, a gene encoding a new antigenic protein from Trypanosoma cruzi called PTc4O is disclosed. The amino acid sequence of the PTc4O protein is also disclosed, along with the amino acid sequence of the dominant antigenic epitope of the PTc4O protein. The PTc40 protein and Tc40 gene, or a fragment thereof, modified or otherwise, can be used directly or indirectly for the detection of Trypanosoma cruzi, or for the monitoring of an infection generated by T. cruzi in man or animals.
L'invention concerne la séquence de nucléotides de Tc40, un gène codant pour une nouvelle protéine antigénique de Trypanosoma cruzi appelée PTc40. L'invention concerne également la séquence d'acides aminés de la protéine PTc40, ainsi que la séquence d'acides aminés de l'épitope antigénique dominant de la protéine PTc40. La protéine PTc40 et le gène Tc40, ou un fragment de celui-ci, modifié ou autre, peut être utilisé directement ou indirectement dans la détection de Trypanosoma cruzi, ou pour la surveillance d'une infection produite par T. cruzi chez l'homme ou chez l'animal.
Jolivet Michel
Lesenechal Mylene
Mandrand Bernard
Paranhos-Baccala Glaucia
Bio Merieux
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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