Trypsin-like serine protease inhibitors, and their...

Details Trypsin-like serine protease inhibitors, and their... Trypsin-like serine protease inhibitors, and their...

C - Chemistry, Metallurgy

07

C

C07C 311/33 (2006.01) A61K 31/18 (2006.01) A61K 31/44 (2006.01) A61P 7/02 (2006.01) C07D 213/56 (2006.01) C07D 213/89 (2006.01) C07D 233/64 (2006.01)

Patent

CA 2667507

The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrien, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.

L'invention concerne des inhibiteurs des sérine protéases de type trypsine de formule générale (I) qui, outre la plasmine, inhibent également la kallicréine plasmatique, ainsi que leur fabrication et leur utilisation en tant que médicament de préférence pour le traitement des pertes de sang, notamment pour les états hyperfibrinolytiques, lors des transplantations d'organes ou des interventions chirurgicales cardiaques avant tout pour les personnes ayant un pontage cardiopulmonaire, ou en tant que composant d'une colle de fibrine.

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