C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61K 33/00 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2546747
Human TTBK genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of TTBK are provided.
Selon l'invention, des gènes des tau-tubuline kinases humains sont identifiés comme étant des modulateurs de la voie de la bêta-caténine, ces gènes constituant ainsi des cibles thérapeutiques pour le traitement de troubles associés à une fonction défectueuse de la bêta-caténine. L'invention concerne des procédés d'identification de modulateurs de la bêta-caténine, lesquels comprennent le criblage d'agents modulant l'activité des tau-tubuline kinases.
Francis-Lang Helen
Heuer Timothy S.
Ventura Richard Benn Abegania
Winter Christopher G.
Zhang Haiguang
Bennett Jones Llp
Exelixis Inc.
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