Ttk in diagnosis and as a therapeutic target in cancer

Details Ttk in diagnosis and as a therapeutic target in cancer Ttk in diagnosis and as a therapeutic target in cancer

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C12N 9/12 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2438092

The present invention provides methods for identification of cancerous cells by detection of expression levels of TTK, as well as diagnostic, prognostic and therapeutic methods that take advantage of the differential expression of these genes in mammalian cancer. Such methods can be useful in determining the ability of a subject to respond to a particular therapy, e.g., as the basis of rational therapy. In addition, the invention provides assays for identifying pharmaceuticals that modulate activity of these genes in cancers in which these genes are involved, as well as methods of inhibiting tumor growth by inhibiting activity of TTK.

La présente invention concerne, d'une part des procédés permettant d'identifier des cellules cancéreuses par détection des niveaux d'expression de la TTK (Tyrosine Thréonine Kinase), et d'autre part des procédés de diagnostic, de pronostic et des traitements qui exploitent les possibilités de l'expression différentielle de ces gènes dans le cancer des mammifères. Ces procédés conviennent pour déterminer l'aptitude d'un sujet à réagir à une thérapie particulière, par exemple comme base d'une thérapie rationnelle. L'invention concerne en outre des essais permettant d'identifier des produits pharmaceutiques qui modulent l'activité de ces gènes dans le cas de cancers où ces gènes sont impliqués, ainsi que des procédés permettant d'inhiber la croissance tumorale par inhibition de l'activité de la TTK.

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