Tuberculosis diagnostic test

Details Tuberculosis diagnostic test Tuberculosis diagnostic test

C - Chemistry, Metallurgy

07

K

C07K 14/35 (2006.01) A61K 31/70 (2006.01) A61K 38/10 (2006.01) C07K 7/08 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2348475

A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognises any of the said peptides, and (ii) determining whether the T cells of said T cell population recognise the peptide(s) and/or analogue(s). The method may be performed in vivo. Peptides and a kit which enable the method to be carried out are provided.

L'invention porte sur une méthode qui permet de diagnostiquer chez un hôte une infection par ou exposition à une mycobactérie exprimant ESAT-6. La méthode consiste à: I) placer une population de lymphocytes T provenant de l'hôte au contact d'un ou plusieurs peptides ou leurs analogues sélectionnés parmi les peptides ou leurs analogues représentés par les séquences SEQ ID No.1 à 11 et pouvant se lier à un récepteur des lymphocytes T capable de reconnaître n'importe lequel desdits peptides; et ii) déterminer si, dans ladite population, les lymphocytes T reconnaissent le(s) peptide(s) et/ou son (ses) analogue(s). La méthode peut être réalisée in vivo. L'invention concerne en outre des peptides et une trousse permettant de mettre en oeuvre ladite méthode.

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