C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) A61K 39/04 (2006.01)
Patent
CA 2647287
The present invention relates to an isolated microorganism belonging to the genus Mycobacterium, characterized in that it comprises inactivating the gene Rv0757 that confers a PhoP- phenotype and inactivating a second gene that prevents the production of DIM (DIM-phenotype). Additionally, the present invention comprises the use of said microorganism for producing a vaccine for immunizing against or preventing tuberculosis.
L'invention porte sur un micro-organisme isolé appartenant au genre Mycobacterium, et caractérisé en ce qu'il permet de désactiver le gène Rv0757 qui confère un phénotype PhoP et de désactiver un deuxième gène qui empêche la production de DIM (phénotype DIM-). L'invention porte également sur l'utilisation dudit micro-organisme dans l'élaboration d'un vaccin d'immunisation contre et de prévention de la tuberculose.
Arbues Arribas Ainhoa
Gicquel Brigitte
Gonzalo Asensio Jesus
Martin Montanes Carlos
Perez Herran Esther
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Universidad de Zaragoza
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