Tubulin inhibitor and process for its preparation

Details Tubulin inhibitor and process for its preparation Tubulin inhibitor and process for its preparation

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2610416

The invention provides 6-chloro-5-{2,6-difluoro-4-[3- (methylamino)propoxy]phenyl}-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1- methylethyl]pyrimidin-4-amine hemifumarate which is a tubulin inhibitor useful in the treatment of cancer and processes of making said hemifumarate.

L'invention concerne 6-chloro-5-{2,6-difluoro-4-[3-(méthylamino)propoxy]phényl}-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-méthyléthyl]pyrimidin-4-amine hémifumarate représentant un inhibiteur de tubuline utile pour le traitement du cancer, ainsi que des méthodes servant à préparer ledit hémifumarate.

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