Tubulin inhibitors

Details Tubulin inhibitors Tubulin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/4418 (2006.01) A61K 31/444 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 237/20 (2006.01) C07D 239/42 (2006.01) C07D 241/20 (2006.01) C07D 253/07 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2545422

Compounds of general formula (I), (II) (III) and (V) are described for use in modulating microtubule polymerisation and in the treatment of associated disease states. Use of compounds (I), (III) and (V) in the treatment of kinase- associated disease states is also described. Further described are novel compounds of formula (II), (III) and (V).

L'invention porte sur des composés des formules générales (I), (II) (III) et (V), qui sont utilisés pour moduler la polymérisation des microtubules et pour traiter les états pathologiques associés. L'invention se rapporte également à l'utilisation des composés (I), (III) et (V) dans le traitement d'états pathologiques associés à la kinase. L'invention concerne enfin de nouveaux composés des formules (II), (III) et (V).

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