C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 51/10 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2151099
A peptide having affinity with tumor or a salt thereof, which comprises an amino acid sequence containing 20 or less amino acid residues, said amino acid sequence being described as X1- YCAREPPT-X2 wherein A, C, E, P, R, T and Y represent amino acid residues expressed by standard one-letter symbols, each of amino acid residues A, C, R and Y in the amino acid sequence YCAR may be in either L-form or D-form, X1 represents a basic organic compound having 1-3 amino groups, and X2 represents any given amino acid sequence, is provided together with a radioactive diagnostic agent and a radioactive therapeutic agent containing the above peptide or a salt thereof. The present tumor affinity peptide is high in radioactive metal labeling yield, useful for imaging and treating pathological tissues such as of breast cancer, ovarian cancer and colon cancer of mammals including human, and difficult to be readily metabolized in organisms and to accumulate in normal tissues especially at kidney and liver.
Itaya Yoshitoshi
Seki Ikuya
Shirakami Yoshifumi
Washino Komei
Goudreau Gage Dubuc
Nihon Medi-Physics Co. Ltd.
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