Tumor antigen

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C07K 16/30 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2450692

A gene encoding a tumor antigen which is recognized by HLA-A2-restricted cytotoxic T lymphocytes (CTL) and/or capable of inducing CTL is identified from a human colorectal caner cell line and a human esophageal cancer cell line. Further, a peptide having the epitope of the above tumor antigen is found out. Moreover, a polypeptide encoded by the above gene or the above- described peptide, a polynucleotide encoding one of them or its complementary strand, a recombinant vector, a transformant, etc. are provided.

L'invention concerne un gène codant pour un antigène tumoral reconnu par des lymphocytes cytotoxiques T (CTL) à restriction HLA-A2 et/ou capable d'induire CTL, qui est identifié par des lignées cellulaires du cancer colorectal humain et du cancer oesophagien humain. L'invention concerne également un peptide comprenant un épitope de l'antigène précité. En outre, l'invention concerne un polypeptide codé par le gène ou le peptide précité, un polynucléotide codant pour l'un d'eux ou son brin complémentaire, un vecteur de recombinaison, et transformant, etc.

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