Tumor antigen

Details Tumor antigen Tumor antigen

C - Chemistry, Metallurgy

07

K

C07K 7/04 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 7/06 (2006.01) C07K 14/28 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2465639

A gene which is recognized by HLA A2 restricted cytotoxic T lymphocytes (CTL) and/or induces CTL is isolated from a human glyoma cell line KNS60 cDNA library and identified. Based on a tumor antigen encoded by the thus obtained gene, a peptide having the epitope of the tumor antigen is found out.

On a isolé dans une banque d'ADNc humain KNS60 d'une ligne cellulaire de gliomes et identifié un gène reconnu par les lymphocytes T cytotoxiques (CTL) restreints par HLA A2 et/ou induisant CTL. On a découvert un peptide possédant le déterminant antigénique de l'antigène tumoral à partir d'un antigène tumoral codé par le gène obtenu.

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