Tumor antigen proteins, genes thereof, and tumor antigen...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2257531

DNAs encoding a protein having the amino acid sequence of SEQ ID NO: 1 or its modifications having the same amino acid sequence except for one or more amino acids having been substituted, deleted or added, provided that this protein and its modifications can form, through intracellular digestion, peptide fragments capable of binding to major histo-compatibility complex (MHC) class I antigens and being recognized by T cells in the bonded state; drugs containing these DNAs as the active ingredient; expression plasmids having these DNAs; transformants transformed by these expression plasmids; and tumor antigen proteins and tumor antigen peptides produced by expressing these DNAs.

La présente invention concerne des ADN codant pour une protéine comportant la séquence d'acide aminé SEQ ID NO: 1 ou pour celles de ses modifications qui comportent la même séquence d'acide aminé, à l'exception d'un ou de plusieurs acides aminés substitués, supprimés ou ajoutés. Toutefois, cette protéine et ses modifications peuvent former, par digestion intracellulaire, des fragments de peptides capables de se lier à des antigènes de classe I de complexes majeurs d'histocompatibilité (CMH), et capables d'être reconnus par les lymphocytes T à l'état lié. L'invention concerne également des médicaments dont les principes actifs sont de tels ADN. L'invention concerne en outre des transformants transformés par ces plasmides. L'invention concerne enfin des protéines d'antigènes tumoraux et des peptides d'antigènes tumoraux produits par l'expression de ces ADN.

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