Tumor-associated antigen derivatives from the mage family,...

Details Tumor-associated antigen derivatives from the mage family,... Tumor-associated antigen derivatives from the mage family,...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) C07K 1/00 (2006.01) C07K 14/11 (2006.01) C07K 14/245 (2006.01) C07K 14/285 (2006.01) C07K 14/315 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2319309

The present invention relates to novel proteins and to their production, from the MAGE family. In particular, to a MAGE protein fused to an immunological fusion partner, such as Lipoprotein D. Such antigens may be formulated to provide vaccines for the treatment of a range of tumours. Novel methods for purifying MAGE proteins are also provided.

L'invention concerne de nouvelles protéines de la famille MAGE et leur production, en particulier une protéine MAGE fusionnée à un partenaire de fusion immunologique, tel qu'une lipoprotéine D. Ces antigènes peuvent être formulés en vue d'obtenir des vaccins pour le traitement de toute une gamme de tumeurs. De nouveaux procédés de purification de protéines MAGE sont également décrits.

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