Tumor associated epitopes

Details Tumor associated epitopes Tumor associated epitopes

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 39/00 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2222551

This invention relates to the epitopes to which monoclonal antibody 88BV59 and antibody 16.88 react. These antibodies were produced by B-cell lines derived from B-cells of cancer patients actively immunized with autologus tumor antigens. Both epitopes are found on the same antigen in tumor tissue. These epitopes can be used in both diagnostic procedures and therapy for human cancers.

L'invention concerne des épitopes auxquels l'anticorps monoclonal 88BV59 et l'anticorps 16.88 réagissent. Ces anticorps ont été produits par des lignées de lymphocytes B dérivées de lymphocytes B de patients atteints de cancer, activement immunisés par des antigènes tumoraux autologues. Ces antigènes que l'on trouve sur le même antigène de tissu tumoral, peuvent être utilisés à la fois dans des procédures diagnostiques et thérapeutiques relatives aux cancers humains.

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