Tumor-associated peptides binding promiscuously to human...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/47 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2621389

The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumour-associated T-helper cell peptide epitopes, alone or in combination with other tumour-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumour immune responses. In particular, the present invention relates to 49 novel peptide sequences derived from HLA class II molecules of human tumour cell lines which can be used in vaccine compositions for eliciting anti-tumour immune responses.

L'invention concerne des procédés d'immunothérapie, et des molécules et des cellules s'utilisant dans de tels procédés. Elle concerne en particulier l'immunothérapie du cancer. L'invention concerne de plus des épitopes peptidiques de lymphocytes T auxiliaires associés aux tumeurs, utilisés seuls ou en combinaison avec d'autres peptides associés aux tumeurs, comme principes actifs pharmaceutiques de compositions vaccinales destinées à stimuler des réponses immunitaires antitumorales. L'invention concerne en particulier 49 nouvelles séquences peptidiques provenant de molécules du HLA de la classe II issues de lignées de cellules tumorales humaines, qui peuvent être utilisées dans des compositions vaccinales pour déclencher des réponses immunitaires antitumorales.

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