Tumor-associated peptides binding to human leukocyte antigen...

Details Tumor-associated peptides binding to human leukocyte antigen... Tumor-associated peptides binding to human leukocyte antigen...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) C12N 15/00 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2621414

The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumour-associated T-helper cell peptide epitopes, alone or in combination with other tumour-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumour immune responses. In particular, the present invention relates to two novel peptide sequences derived from HLA class II molecules of human tumour cell lines which can be used in vaccine compositions for eliciting anti-tumour immune responses.

La présente invention concerne des procédés immunothérapeutiques, et des molécules et cellules pour utilisation dans des procédés immunothérapeutiques. En particulier, la présente invention concerne l'immunothérapie contre le cancer. La présente invention concerne en outre des épitopes de cellule T auxiliaire associés aux tumeurs, seuls ou en combinaison avec d'autres peptides associés aux tumeurs, qui servent d'ingrédients pharmaceutiques actifs de compositions de vaccin qui stimulent des réponses immunitaires antitumeur. En particulier, la présente invention concerne deux nouvelles séquences peptidiques dérivées de molécules de HLA de classe II de lignées de cellules de tumeur humaine qui peuvent être utilisées dans des compositions de vaccin pour provoquer des réponses immunitaires antitumeur.

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