Tumor cell invasion-inhibiting peptides, peptide complexes...

Details Tumor cell invasion-inhibiting peptides, peptide complexes... Tumor cell invasion-inhibiting peptides, peptide complexes...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 7/08 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2074945

- 36 - ABSTRACT The present invention is a peptide having from 5 to 20 amino acid residues having tumor cell invasion- inhibiting activities. As such a peptide, a peptide represented by any one of the formulas (1) to (13) is preferred among peptides having the following amino acid sequences. Further, the present invention is a cancer metastasis inhibitor comprising the above peptide as an active ingredient. Furthermore, the present invention is a peptide complex having a peptide having tumor cell invasion- inhibiting activities and a polymer derived from a vital body chemically bonded to each other. As such a peptide, a peptide represented by any one of the formulas (1) to (14) is preferred among peptides having the following amino acid sequences. As the polymer derived from a vital body, a protein such as albumin or globulin is preferred. Still further, the present invention is a cancer metastasis inhibitor comprising the above peptide complex as an active ingredient. (1) Ala-Glx-Lys-Ala-Glx-Gly (2) Ala-Glx-Lys-Ala-Glx-Gly-Ala (3) Ala-Glx-Lys-Ala-Glx-Gly-Ala-Gly (4) Ala-Glx-Lys-Ala-Glx-Gly-Ala-Gly-Asx (5) Ala-Glx-Lys-Ala-Glx-Gly-Ala-Gly-Asx-Ala - 37 - (6) Ala-Glx-Lys-Ala-Glx-GIy-Ala-C.ly-Asx-Ala-Lys (7) Asx-Ala-Lys-Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly (8) Ala-Lys-Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly (9) Lys-Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly (10) Thr-Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly (11) Asx-Glx-Ala-Glx-Lys-Ala-Glx-Gly (12) Glx-Ala-Glx-Lys-Ala-Glx-Gly (13) Asx-Glx-Ala-Glx-Lys-Ala (14) Ala-Glu Asp-Gly-Asp-Ala-Lys-Thr-Asp-Glx-Ala-Glx- Lys-Ala-Glu-Gly-Ala-Gly-Asp-Ala-Lys wherein Glx is Glu or Gln, and Asx is Asn or Asp.

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