Tumor cytotoxicity induced by modulators of the cxcr4 receptor

A - Human Necessities – 61 – K

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A61K 38/08 (2006.01) A61K 35/76 (2006.01) A61K 38/16 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2525873

The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form.

L'invention porte sur un moyen sélectif de destruction de carcinomes de cellules épithéliales par administration d'une séquence spécifique du récepteur CXCR4 de la protéine Gp120 ou de protéines Nef, ou des protéines elles-mêmes (les modulateurs) telles que celles qu'on trouve dans les souches de VIH-1, VIH-2, VIS, ou VIF. L'administration des séquence spécifique du récepteur CXCR4 de la protéine Gp120 ou des protéines Nef ou de leurs séquences peut se faire par voie transmuqueuse ou systémique. L'administration transmuqueuse peut être orale, intra-nasale, oculaire, intravaginale, rectale, et/ou intrauréthrale, et sous forme liquide ou particulaire.

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