Tumor-homing cells engineered to produce tumor necrosis...

Details Tumor-homing cells engineered to produce tumor necrosis... Tumor-homing cells engineered to produce tumor necrosis...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/078 (2010.01) A61K 35/14 (2006.01) A61P 35/00 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2571426

The invention refers to tumor-homing cells expressing the tumor necrosis factor-related apoptosis inducing ligand (TRIAL), particularly to CD34+ and NK cells transduced with adenoviral vectors coding for TRIAL. The cells of the invention are useful for the intravenous treatment of tumors, particularly of lymphoma.

La présente invention a trait à des cellules de localisation tumorale d'expression du ligand inducteur d'apoptose relié au facteur de nécrose tumorale (TRAIL), notamment aux cellules CD34+ et NK transduites avec des vecteurs adénoviraux codant pour le ligand TRAIL. Les cellules de l'invention sont utiles pour le traitement par voie intraveineuse de tumeurs, en particulier de lymphome.

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