C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/315 (2006.01) A61K 35/14 (2006.01) A61K 35/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) C07K 14/31 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2078003
Staphylococcal enterotoxins obtained by secretion from Staphylococcus aureus, by expression of enterotoxins in other bacteria or cells, or by chemical mutagenic treatment of S. aureus strains are used in treatment of cancer as tumorcidal agents. Enterotoxins (A, B, C, D, E and F) can be administered via simple intravenous injection at dosages between 0.5 µg/kg body weight to 150 µg/kg. Non-steroidal, anti-inflammatory agents and prostaglandin synthesis inhibitors such as ibuprofen may be simultaneously administered to attenuate toxic reactions from the enterotoxins. Streptococcus pyrogenic exotoxin and alpha hemolysin, which nave structural and functional homology to the enterotoxins, are also useful in tumoricidal treatment. The enterotoxin gene transfected into tumor cells resulting in a tumor cell with surface expression of the minor lymphocyte stimulating locus with consequent patent activation and proliferation of T lymphocytes especially those with V.beta. specificity, would also be useful in this application.
Stone Jay L.
Terman David S.
Smart & Biggar
Stone Jay L.
Terman David S.
LandOfFree
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