C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/46 (2006.01) A61K 31/4709 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01) C07D 409/12 (2006.01) C07D 487/08 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2645546
Inhibitors of tumor necrosis factor alpha are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with tumor necrosis factor alpha. The inhibitors of tumor necrosis factor alpha have the following structures: (I) including stereoisomers, pharmaceutically acceptable salts, and solvates thereof, wherein substituents are as defined herein. Compositions containing an inhibitor of tumor necrosis factor alpha in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
L'invention porte sur des inhibiteurs du facteur de nécrose tumorale alpha utiles pour le traitement de divers troubles dont le traitement d'états pathologiques associés audit facteur. Lesdits inhibiteurs présentent les structures (I) dont les substituants sont définis dans la description. L'invention porte également sur leurs stéréoisomères, leurs sels pharmacocompatibles, leurs solvates, sur des compositions les contenant avec un support pharmacocompatibles, et sur leurs méthodes d'utilisation.
Aichholz Reiner
Billich Andreas
Davis Timothy James
Kumar Sunil K.c.
Nussbaumer Peter
Avanir Pharmaceuticals
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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