A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/35 (2006.01) A61K 31/352 (2006.01)
Patent
CA 2231764
Pharmaceutical compositions are described for preventing TNF toxicity, comprising as active ingredient the stereospecific (+) enantiomer, having (3S, 4S) configuration of .DELTA.6 tetrahydrocannabinol type compounds. The compositions are particulary effective in alleviating and even preventing neurotoxicity due to elevated levels of TNF, including septic shock, cachexia and trauma. They are also effective in the treatment of certain chronic degenerative diseases characterized by TNF production, including autoimmune diseases.
La présente invention concerne des compositions pharmaceutiques destinées à prévenir la toxicité du TNF. Les principes actifs de telles compositions sont l'énantiomère stérospécifique (+) de configuration (3S,4S) des composés de type .DELTA.?6¿ tétrahydrocannabinol. Ces compositions conviennent particulièrement pour l'atténuation voire la prévention de la neurotoxicité imputable aux niveaux élevés de TNF, et également au choc septique, à la cachexie et aux lésions. Ces compositions conviennent également au traitement de certaines affections chroniques dégénératives caractérisées par une production de TNF, y compris des affections auto-immunes.
Gallily Ruth
Mechoulam Raphael
Shohami Esther
Osler Hoskin & Harcourt Llp
Yissum Research Development Company Of The Hebrew University Of
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