Tumor necrosis factor receptor-derived peptide analogues

Details Tumor necrosis factor receptor-derived peptide analogues Tumor necrosis factor receptor-derived peptide analogues

A - Human Necessities

61

K

A61K 38/00 (2006.01) C07K 7/50 (2006.01) C07K 7/64 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2291963

The present invention relates to peptides and peptide analogues designed from a binding loop of a member of the tumor necrosis factor receptor (TNF-R) superfamily. In particular, it relates to cyclic peptides and peptide analogues designed from a binding loop of TNF-R which inhibit TNF binding to its cellular receptors, and methods of making and using such compounds to inhibit the biological activities of TNF.

Peptides et analogues de peptides construits à partir de la boucle de liaison d'un membre de la superfamille des récepteurs de facteur de nécrose des tumeurs (TNF-R). L'invention concerne en particulier des peptides cycliques et des analogues de peptides construits avec une boucle de liaison de TNF-R, qui inhibent la liaison du TNF à ses récepteurs cellulaires, ainsi que des procédés pour préparer et utiliser ces composés pour inhiber les activités biologiques du TNF.

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