Tumor necrosis factor receptor homologue-1 ("trh1")

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/715 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/64 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2354612

The present invention discloses the identification of the new human tumor necrosis factor receptor homologue ("TRH1"), as identified by its nucleic acid and amino acid sequences disclosed herein. The invention also includes methods of using the nucleic acid sequence, the TRH1 protein, a monoclonal antibody specific for the novel tumor necrosis factor receptor, a ligand for the novel tumor necrosis factor receptor, and fusion proteins comprising all or a portion of the TRH1 disclosed herein.

La présente invention concerne l'identification du nouvel homologue récepteur du facteur de nécrose tumorale (TRH1), de même que ses séquences d'acide nucléique et d'acide aminé qui l'identifie. Cette invention concerne aussi des techniques d'utilisation de ces séquences d'acide nucléique, de la protéine TRH1, d'un anticorps monoclonal spécifique au récepteur du facteur de nécrose tumorale, d'un ligand du nouveau récepteur du facteur de nécrose tumorale, et de protéines hybrides comprenant tout ou partie du TRH1 de l'invention.

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