C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 16/24 (2006.01) C07K 17/08 (2006.01) C12N 15/85 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2256464
A novel member of the tumor necrosis factor (TNF) family was identified and observed to be involved in inflammation and necrosis, especially of the liver, myelopoiesis and bone resorption. The polypeptide is termed AGP-1. Nucleic acid sequences, vectors and host cells for the expression of AGP-1 are disclosed. Methods for identifying antagonists of AGP-1, pharmaceutical compositions comprising AGP-1 and methods of treatment using AGP-1 and AGP-1 antagonists are also disclosed.
On a identifié un nouveau membre de la famille du facteur de nécrose tumoral et on a découvert son implication dans l'inflammation et la nécrose, en particulier du foie, la myélopoïèse et la résorption osseuse. On désigne le polypeptide par AGP-I. Des séquences nucléotidiques, des vecteurs et des cellules hôtes pour l'expression d'AGP-1 sont décrites, ainsi que des procédés d'identification d'antagonistes d'AGP-1, des compositions pharmaceutiques contenant AGP-1 et des méthodes de traitement à l'aide d'antagonistes d'AGP-1 et AGP-2.
Danilenko Dimitry Michael
Johnson Merrie Jo
Simonet William Scott
Amgen Inc.
Gowling Lafleur Henderson Llp
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