C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/28 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2221830
TR6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR6 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (e.g. inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer (e.g. lymphoproliferative disorders), atheroschlerosis, and Alzheimers disease., among others and diagnostic assays for such conditions.
On divulgue des polypeptides et des polynucléotides TR6 et des méthodes pour produire ces polypeptides par les techniques de recombinaison. On divulgue également des méthodes pour utiliser les polypeptides et polynucléotides TR6 dans la conception de protocoles pour le traitement de l'inflammation chronique et aiguë, de l'arthrite, de la septicémie, des maladies autoimmunes (p. ex. maladie intestinale inflammatoire, psoriasis), le rejet d'une transplantation, la réaction du greffon contre l'hôte, l'infection, l'accident cérébro-vasculaire, l'ischémie, le syndrome de détresse respiratoire aiguë, la resténose, les lésions cérébrales, le sida, les maladies osseuses, le cancer (p. ex. troubles lymphoprolifératifs), l'athérosclérose et la maladie d'Alzheimer, entre autres, et les épreuves diagnostiques pour ces affections.
Deen Keith Charles
Young Peter Ronald
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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