Tumor necrosis related receptor, tr4

Details Tumor necrosis related receptor, tr4 Tumor necrosis related receptor, tr4

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2220852

TR4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR4 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, autoimmune diseases (eg inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer (eg lymphoproliferative disorders), atheroschlerosis, and Alzheimers disease among others, and diagnostic assays for such conditions.

Polypeptides et polynucléotides TR4, et mode de fabrication de ces polypeptides par la technique de l'ADN recombinant. Sont également décrites les méthodes permettant d'utiliser les polypeptides et les polynucléotides TR4 dans la conception de protocoles pour traiter, entre autres, les inflammations chroniques et aiguës, l'arthrite, les maladies autoimmunes (p. ex. une maladie intestinale inflammatoire, le psoriasis), le rejet de greffes, la réaction du greffon contre l'hôte, les infections, les accidents vasculaires cérébraux, les atteintes respiratoires aiguës, la resténose, les lésions cérébrales, le sida, les maladies osseuses, le cancer (p. ex. les affections lymphoprolifératives), l'athérosclérose et la maladie d'Alzheimer, de même que les épreuves diagnostiques pour ces affections.

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