Tumor necrosis related receptor, tr5

Details Tumor necrosis related receptor, tr5 Tumor necrosis related receptor, tr5

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2221687

TR5 polypeptides and polynucleotides and methods for producing such polypeptidesby recombinant techniques are disclosed. Also disclosed are methods for utilizing TR5 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (eg inflammatory bowel disease, graft vs. host disease), transplantation, infection, stroke, ischemia, acute respiratory disease syndrome, psoriasis, restenosis, brain injury, AIDS, Bone diseases, cancer (eg lymphoproliferative disorders),atherosclerosis and Alzheimers disease among others, and diagnostic assays for such conditions.

L'invention porte sur des polypeptides et polynucléotides TR5 ainsi que sur des méthodes de fabrication de tels polypeptides au moyen de techniques de recombinaison. L'invention divulgue également des méthodes d'utilisation des polypeptides et polynucléotides TR5 dans la conception de protocoles pour le traitement, entre autres, des inflammations chroniques et aiguës, de l'arthrite, de la septicémie, des maladies auto-immunes (notamment les maladies intestinales inflammatoires, les réactions du greffon contre l'hôte), des transplantations, des infections, des accidents cérébrovasculaires, des ischémies, des atteintes respiratoires aiguës, du psoriasis, de la resténose, des lésions cérébrales, du SIDA, des affections osseuses, du cancer (notamment des affections lymphoprolifératives), de l'athérosclérose et de la maladie d'Alzheimer. Elle porte aussi sur des méthodes diagnostiques pour de telles affections.

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