Tumor necrosis related receptor, tr7

Details Tumor necrosis related receptor, tr7 Tumor necrosis related receptor, tr7

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2233785

TR7 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR7 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (such as inflammatory bowel disease and psoriasis), transplant rejection, graft versus host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, bone disease, cancer (such as lymphoproliferative disorders), atherosclerosis, and Alzheimers disease, among others and diagnostic assays for such conditions.

Divulgation de polypeptides et de polynucléotides TR7, ainsi que de méthodes de production de tels polypeptides par des techniques de recombinaison. Sont également dévoilées des méthodes d'utilisation de ces produits dans la conception de protocoles pour le traitement de l'inflammation chronique et aiguë, de l'arthrite, de la septicémie, des maladies auto-immunes (comme la maladie intestinale inflammatoire et le psoriasis), du rejet de greffes, de la réaction du greffon contre l'hôte, des infections, des accidents cérébrovasculaires, de l'ischémie, du syndrome de détresse respiratoire aiguë, de la resténose, des lésions cérébrales, du SIDA, de la maladie des os, du cancer (comme les affections lymphoprolifératives), de l'athérosclérose et de la maladie d'Alzheimer, entre autres, ainsi que les épreuves de diagnostic de ces affections.

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