Tumor or cancer cell killing therapy and agents useful therefor

Details Tumor or cancer cell killing therapy and agents useful therefor Tumor or cancer cell killing therapy and agents useful therefor

A - Human Necessities

61

K

167/179, 358/23

A61K 31/00 (2006.01) A61K 33/24 (2006.01) A61K 38/45 (2006.01) A61N 5/00 (2006.01)

Patent

CA 1336409

The effectiveness of cytostatic and/or cytotoxic drugs and/or radiation in the killing of tumor and/or cancer cells is increased by the administration, along with said drugs and radiation, of an effective activat- ing or inhibiting amount of a compound or agent which activates or inhibits the chromatin-bound enzyme adeno- sine diphosphate ribosyl transferase (ADPRT) or the ad- ministration of an effective intracellular free Ca++- increasing amount of a compound which induces cellular or oxidative stress or which acts as an inhibitor or antagonist or calmodulin or Ca++-calmodulin binding. Suitable such compounds or agents include the pheno- thiazines, antihistamines, butyrophenones, cannabinoids and corticosteriods and particularly metoclopramide when employed in combination with cisplatin.

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