Tumor rejection antigen precursors, tumor rejection antigens...

Details Tumor rejection antigen precursors, tumor rejection antigens... Tumor rejection antigen precursors, tumor rejection antigens...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 35/18 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2109727

The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it. Also described are cells transfected by the DNA sequence, and various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes.

L'invention se rapporte à une séquence d'ADN isolée qui code pour un antigène exprimé par des cellules tumorales qui sont reconnues par des lymphocytes T cytotoxiques, et provoquant la lyse de la tumeur qui l'exprime. On décrit aussi des cellules transférées par la séquence d'ADN, et différentes utilisations thérapeutiques et diagnostiques découlant des caractéristiques de l'ADN et de l'antigène pour lequel il code.

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