C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/314, 260/329
C07F 15/00 (2006.01)
Patent
CA 1268182
ABSTRACT OF THE DISCLOSURE There are described (1-benzyl- ethylenediamine)-platin(II)- complexes of the general formula: Image wherein the radicals R1, R2, R3, and R4 are the same or different and are hydrogen, a C1-C6-alkyl group, C1 henzyl group, or a phenylethyl group, and B is a thienyl radical, an indolyl radical, an imidazolyl radical, or a phenyl radical substituted by the radicals R5, R6, and R7 which are the same or different and are hydrogen, halogen, trihalomethyl, C1-C6- alkyl, hydroxy, C1-C6-alkoxy, phenoxy, benzyloxy, C1-C6- alkanoyloxy, benzoyloxy, C1-C6- alkanesulfonyloxy, carboxy, C1-C6-carbalkoxy, cyano, aminocarboxyl , aminocarbonyl, which contains one or two C1-C6-alkyl radicals, C1-C6- alkylcarbonyl, nitro, amino, C1-C6-alkylamino, di-C1-C6- alkylamino, C1-C6-alkyl)3N+, C1-C6-alkanoylamino, C1-C"- alkyl- C1-C6-alkanoylamino, C1-C6-alkanesulfonylamino, C1- C6-alkyl-C1-C6-alkanesulfonylamino, aminosulfonyl, aminosulfonyl which contains one or two C1-C6-alkyl radicals, C1-C6-alkoxysulfonyl (-SO2-0-C1-C6-alkyl), sulfo (-SO3H) or C1-C6-alkanesulfonyl and two of these groups can be the methylenedioxy group and X is the equivalent of a physiologically compatible anion, as well as optionally their salts with physiologically compatible cations and anions and process of their production. The complexes have good antitumor activity with good compatiblity.
502459
Brunner Henri
Engel Jurgen
Holzinger Ulrich
Schmidt Manfred
Schonenberger Helmut
Asta Pharma Aktiengesellschaft
Brunner Henri
Engel Jurgen
Holzinger Ulrich
Marks & Clerk
LandOfFree
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