Tumor specific human monoclonal antibodies and methods of use

Details Tumor specific human monoclonal antibodies and methods of use Tumor specific human monoclonal antibodies and methods of use

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2353703

The invention provides tumor-specific human monoclonal antibodies and functional fragments. Also provided are nucleic acids encoding tumor-specific human monoclonal antibodies and functional fragments. A method for reducing neoplastic cell proliferation is also provided. The method consists of administering an effective amount of a tumor-specific human monoclonal antibody or functional fragment. Also provided is a method of detecting a neoplastic cell in a sample. The method consists of contacting a cell with a tumor-specific monoclonal antibody or functional fragment and detecting the specific binding of the human monoclonal antibody or functional fragment to the sample.

L'invention concerne des anticorps monoclonaux humains spécifiques des tumeurs et des fragments fonctionnels. L'invention concerne également des acides nucléiques codant pour lesdits anticorps monoclonaux humains spécifiques de tumeurs et lesdits fragments fonctionnels. L'invention concerne, en outre, une technique permettant de réduire la prolifération des cellules néoplasiques. Le procédé consiste à administrer une quantité efficace d'un anticorps monoclonal humain spécifique d'une tumeur ou un fragment fonctionnel. L'invention concerne également une technique permettant de détecter une cellule néoplasique dans un échantillon. Ledit procédé consiste à administrer un anticorps monoclonal humain spécifique d'une tumeur ou un fragment fonctionnel, et à détecter la liaison spécifique dudit l'anticorps monoclonal humain ou l'agent fonctionnel dans l'échantillon.

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