Tumor-specific t cell activation by peptide antigens

Details Tumor-specific t cell activation by peptide antigens Tumor-specific t cell activation by peptide antigens

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 31/711 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 15/10 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/06 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2417570

Tumor antigen inducing and/or activating HLA-A2-restricted tumor-specific cytotoxic T lymphocytes that is activated by recognizing HLA-A2 and a tumor antigen peptide, and a peptide or polypeptide derived from the tumor antigen, a polynucleotide encoding the peptide or a complementary strand polynucleotide thereof, a transformant comprising a recombinant vector which comprises the polynucleotide are provided.

L'invention concerne un antigène associé aux tumeurs induisant et/ou activant une cellule T cytotoxique spécifique aux tumeurs non permissive HLA-A2, laquelle cellule reconnaît HLA-A2 et un peptide antigène associé aux tumeurs et est ainsi activée; un peptide ou un polypeptide dérivé de cet antigène associé aux tumeurs; un polynucléotide codant pour le polypeptide susmentionné ou un polynucléotide qui est un brin complémentaire de celui-ci; un transformant contenant un vecteur recombiné qui contient le polynucléotide susmentionné, etc.

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