Tumor-targeting monoclonal antibodies to fzd10 and uses thereof

Details Tumor-targeting monoclonal antibodies to fzd10 and uses thereof Tumor-targeting monoclonal antibodies to fzd10 and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2655289

The present invention relates to an antibody or a fragment thereof which is capable of binding to a Frizzled homologue 10 (FZD10) protein, such as a mouse monoclonal antibody, a chimeric antibody and a humanized antibody. Also, the present invention relates to a method for treating and/or preventing FZD10-associated disease; a method for diagnosis or prognosis of FZD10-associated disease; and a method for in vivo imaging of FZD10 in a subject.

La présente invention concerne un anticorps ou un fragment de cet anticorps qui est susceptible de se lier à une protéine homologue Frizzled 10 (FZD10), tel qu'un anticorps monoclonal de souris, un anticorps chimérique et un anticorps humanisé. La présente invention concerne également un procédé destiné au traitement et/ou à la prévention d'une maladie associée à la FZD10, un procédé permettant de diagnostiquer ou de pronostiquer une maladie associée à la FZD10, et un procédé de technique d'imagerie in vivo de la FZD10 chez un sujet.

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