Tumor therapy with an antibody for vascular endothelial...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2645891

The present invention provides a method of treating a breast cancer disease in a patient who has failed prior treatment with an anti-VEGF antibody, comprising administering to the patient a therapeutically effective amount of an anti-HER2 antibody while continuing said anti-VEGF antibody therapy. The invention also provides corresponding articles of manufacture and pharmaceutical compositions.

La présente invention concerne une méthode destinée au traitement du cancer du sein chez une patiente pour laquelle un traitement à l'aide d'un anticorps anti-VEGF n'a pas été concluant, consistant à administrer à la patiente une dose thérapeutique d'un anticorps anti-HER2 tout en continuant la thérapie avec l'anticorps anti-VEGF. L'invention concerne également des articles de fabrication et des compositions pharmaceutiques correspondants.

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