Tumor tissue microarrays for rapid molecular profiling

Details Tumor tissue microarrays for rapid molecular profiling Tumor tissue microarrays for rapid molecular profiling

C - Chemistry, Metallurgy

40

B

C40B 50/00 (2006.01) C40B 40/00 (2006.01) C40B 60/00 (2006.01) C40B 60/12 (2006.01) G01N 1/36 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2627799

An array-based technology facilitates rapid correlated gene copy number and expression profiling of a very large numbers of human tumors. Hundreds of cylindrical tissue biopsies (diameter 0.6 mm) from morphologically representative regions of individual tumors can be arrayed in a single paraffin block. Consecutive sections from such arrays provide targets for parrallel in situ visualization and quantitation of DNA, RNA or protein targets. For example, amplifications of six loci (mybL2, erbB2, Cyclin- D1, myc, 17q23 and 20q13) were rapidly determined by fluorescence in situ hybridization from 372 ethanol-fixed breast cancers. Stratification of tumors by estrogen receptor and p53 expression data revealed dictinct patterns of gene amplification in the various subgroups of breast cancer that may have prognostic utility. The tissue array technology is useful in the rapid molecular profiling of hundreds of normal and pathological tissue specimens or cultured cells.

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