Tumour-associated peptides binding to mhc molecules

Details Tumour-associated peptides binding to mhc molecules Tumour-associated peptides binding to mhc molecules

C - Chemistry, Metallurgy

07

K

C07K 7/00 (2006.01) A61K 38/08 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2520497

The invention relates to a tumour-associated peptide having an amino acid sequence selected from the group consisting of SEQ ID No. 1 to SEQ ID No. 101 from the associated sequence protocol, said peptide being able to bind to a molecule of the human major histocompatibility complex (MHC) class I. The invention also relates to the use of said peptides and the nucleic acids coding therefor, for producing a medicament and for the treatment of tumour diseases and/or adenomatous diseases. The invention further relates to a pharmaceutical composition comprising at least one of said peptides.

L'invention concerne un peptide associé à une tumeur, présentant une séquence aminoacide choisie à partir du groupe formé par SEQ ID-Nr. 1 à SEQ ID-Nr. 101 à partir d'un protocole de séquence associé, ledit peptide étant capable de se lier à une molécule du complexe majeur d'histocompatibilité humain (MHC) classe I. L'invention concerne en outre l'utilisation des peptides précités et des acides nucléiques codant pour ces peptides, pour la fabrication d'un médicament, et pour le traitement de maladies tumorales et/ou adénomateuses. L'invention concerne également une composition pharmaceutique comprenant au moins l'un desdits peptides.

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