C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2413502
A polynucleotide comprising an Skp 2 promoter sequence is provided. The promoter is useful in tumour and cancer therapy, in particular in therapies that are intended to selectively kill or reduce the growth, division or viability of tumour or cancer cells compared to surrounding, non-tumour or non- cancer cells. Also provided are methods for screening for inhibitors of Skp2 promoter activity.
L'invention concerne un polynucléotide comprenant une séquence promoteur de Skp2. Le promoteur est utile dans le traitement des tumeurs et du cancer, notamment dans des traitements destinés soit à tuer des cellules tumorales ou cancéreuses, soit à réduire la croissance, la division ou la viabilité de ces dernières, plutôt qu'à entourer des cellules non tumorales ou non cancéreuses. L'invention concerne également des procédés de criblage afin d'identifier des inhibiteurs de l'activité du promoteur de Skp2.
Gallani Anne-Isabelle
Imbert Georges
Krek Wilhelm
Fetherstonhaugh & Co.
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miesche
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