Tumour-inhibiting saccharide conjugates

Details Tumour-inhibiting saccharide conjugates Tumour-inhibiting saccharide conjugates

C - Chemistry, Metallurgy

07

H

167/199, 260/228

C07H 11/04 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2001129

The invention relates to a method for the preparation of glyco-conjugates of phosphorus amides with the general formula (See formula 1) where the connection of the sugar with the phosphorus amide-lost residue, and the ifosfamide-lost residue, resp., occurs preferably in the 1-position, and where R1 and R2, which can be the same or different, denote hydrogen, lower C1-C4 alkyl or C1-C6 haloalkyl and where as sugar there can be present mono-, di-, or polysaccharides in all existing isomeric and enantiomeric forms, wherein in a known way protected bromium sugars are conjugated with the respective phosphorus compounds, and freed of the protective residues, and to the use of said compounds as anti-tumour drugs.

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